2-Methyl-2-(methylamino)propanamide → 2-[1-(2,4-dichloro-phenyl)-5-(4-fluoro-phenyl)-4-methyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-one

Participants

Reaction Steps

Compound 19 was synthesized from 4g (248 mg, 0.68 mmol) and 5a (130 mg, 1.08 mmol) as a white solid (121 mg, 39%) in a manner similar to that described in Example 36. 1H NMR (400 MHz, CDCl3) δ 7.39 (d, 1H), 7.20 (dd, 1H), 7.13 (d, 1H), 7.06 (dd, 2H), 6.97 (dd, 2H), 3.43 (s, 3H), 2.33 (s, 3H), 1.36 (s, 6H); ESMS m/z: 445.0 (M+1).

Provenance & Evidence