Glycinamide hydrochloride → 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-3,5-dihydro-imidazol-4-one

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Reaction Steps

Compound 26 was synthesized from 4c (1.0 g, 2.53 mmol) and 2-amino-acetamide hydrochloride (5k) (0.56 g, 4.56 mmol) as a white solid (0.81 g, 73%) in a manner similar to that described in Example 53. 1H NMR (400 MHz, CDCl3) δ 7.43 (d, 1H), 7.31 (d, 2H), 7.30˜7.27 (m, 2H), 7.07 (d, 2H), 4.35 (d, 2H), 2.77 (q, 2H), 1.20 (t, 3H); ESMS m/z: 433.1 (M+1).

Provenance & Evidence