Methyl iodide → 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-3,5,5-trimethyl-3,5-dihydro-imidazol-4-one

Participants

Role	Name	HCID	Charge
Reactant	Methyl iodide	HCID 6328	—
Reactant	2-[5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-5,5-dimethyl-3,5-dihydro-imidazol-4-one	HCID 44191880	—
Product	2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-3,5,5-trimethyl-3,5-dihydro-imidazol-4-one	HCID 44191883	—

Reaction Steps

Compound 28 was synthesized from compound 24 (101 mg, 0.22 mmol) and methyl iodide (2 g, 14.08 mmol) as a white solid (70 mg, 68%) in a manner similar to that described in Example 57. 1H NMR (400 MHz, CDCl3) δ 7.42 (br s, 1H), 7.29 (d, 2H), 7.24 (d, 1H), 7.19 (d, 1H), 7.07 (d, 2H), 3.21 (s, 3H), 2.62 (q, 2H), 1.85 (s, 6H), 1.11 (t, 3H); ESMS m/z: 475.1 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08354442B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-79ba061b470f4ffc8f94e6c08fcaf4a7
Source note	uspto-grants-2013_01