Butyl bromide → 3-butyl-2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-3,5-dihydro-imidazol-4-one

Participants

Reaction Steps

Compound 30 was synthesized from 26 (102 mg, 0.23 mmol) and n-butyl bromide (500 mg, 3.65 mmol) as a white solid (55 mg, 49%) in a manner similar to that described in Example 59. 1H NMR (400 MHz, CDCl3) δ 7.44 (d, 1H), 7.30 (d, 2H), 7.25 (dd, 1H), 7.17 (d, 1H), 7.09 (d, 2H), 4.83 (s, 0.82H), 4.45 (s, 1.18H), 3.80 (s, 1.18H), 3.67 (s, 0.82H), 2.65 (q, 2H), 1.69 (br s, 2H), 1.42-1.25 (m, 2H), 1.13 (t, 3H), 0.97-0.86 (m, 3H); ESMS m/: 489.1 (M+1).

Provenance & Evidence