HCID 68423194, compound → HCID 59317143, compound

Participants

Reaction Steps

A mixture of 43 (118 mg, 0.24 mmol) and Pd—C (12 mg) in MeOH (8 mL) was stirred under 1 atm of H2 at room temperature for 2 h. The reaction mixture was filtered and the resulting filtrate was concentrated under reduced pressure to give the crude residue, which was subjected to purification by flash chromatography on silica gel with hexanes/ethyl acetate (1:1) to afford the product 44 (75 mg, 62%) as a white solid. 1H NMR (400 MHz, CDCl3) δ 7.48 (d, 1H), 7.29 (m, 2H), 6.77 (d, 1H), 6.61 (d, 1H), 3.57 (s, 3H), 2.65 (m, 5H), 1.60 (m, 8H), 1.22 (m, 4H), 0.81 (t, 3H); ESMS m/z: 503.0 (M+1).

Provenance & Evidence