反应详情

温度

80 °C

To a solution of (RS)-4-{4-[3-(4-chloro-phenyl)-ureido]-phenyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (0.24 g) in acetonitrile (3 ml) were added water (9 ml) and trifluoroacetic acid (0.33 ml). The mixture was heated overnight at 80° C. The mixture was then cooled to room temperature and diluted with ethyl acetate/THF (1:1). The resulting mixture was washed sequentially with 1 N aq. sodium hydroxide solution and saturated brine, the phases were then separated and the organic phase was dried over sodium sulphate and concentrated in vacuo to afford (RS)-1-[4-(1-amino-2-hydroxy-ethyl)-phenyl]-3-(4-chloro-phenyl)-urea (0.22 g, quant.) an off-white solid. MS (ISP): 291.1 ([{37Cl}M+H—OH]+), 289.1 ([{35Cl}M+H—OH]+).

1. temperatureThe mixture was then cooled to room temperature
2. washThe resulting mixture was washed sequentially with 1 N aq. sodium hydroxide solution and saturated brine
3. customthe phases were then separated
4. dry with materialthe organic phase was dried over sodium sulphate
5. concentrationconcentrated in vacuo