HCID 67151507, compound → HCID 67151495, compound

Participants

Reaction Steps

To a stirred suspension of (S)-4-((E)-2-{4-[3-(4-chloro-phenyl)-ureido]-phenyl}-vinyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (57 mg) in methanol (8 ml) was added platinum(IV) oxide (14 mg) and the mixture was then stirred under an atmosphere of hydrogen at room temperature for 1 hour. The mixture was then filtered through celite and the filtrate was concentrated in vacuo to afford (S)-4-(2-{4-[3-(4-chloro-phenyl)-ureido]-phenyl}-ethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (60 mg, quant) as an off-white solid. MS (ISP): 476.2 ([{37Cl}M−H]+), 474.3 ([{35Cl}M−H]+), 420.2 ([{37Cl}M+H—C4H8]+), 418.3 ([{35Cl}M+H—C4H8]+).

Provenance & Evidence