Triethylamine → HCID 86653290, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred suspension of (S)-4-[2-(4-amino-phenyl)-ethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (600 mg, example 14 (b)) in dichloromethane (10 ml) were added sequentially triethylamine (0.52 ml) and triphosgene (206 mg) and the mixture was heated at 50° C. for 18 h. The mixture was then concentrated in vacuo and to the residue was added diethyl ether. After stirring for 10 min at room temperature the resulting crystals were removed by filtration. The filtrate was concentrated in vacuo to give (S)-4-[2-(4-isocyanato-phenyl)-ethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (610 mg, 94%) as a yellow oil which was used immediately in the next step without further purification.

Provenance & Evidence