HCID 67151589, compound → (S)-4-[2-(4-amino-phenyl)-ethyl]-4,5-dihydro-oxazol-2-ylamine

Participants

Reaction Steps

(S)-4-[(E)-2-(4-Nitro-phenyl)-vinyl]-4,5-dihydro-oxazol-2-ylamine (0.95 g) was dissolved in methanol (40 ml) before addition of Pd/C 10% (95 mg). The reaction mixture was hydrogenated for 1 hour at room temperature and then the catalyst was filtered off and washed with methanol. The residue was concentrated in vacuo and purified by Isco chromatography (column: Silicycle Si-Amine, AcOEt) to afford (S)-4-[2-(4-amino-phenyl)-ethyl]-4,5-dihydro-oxazol-2-ylamine (800 mg) as an off-white solid. MS (ISP): 206.2 ([M+H]+).

Provenance & Evidence