HCID 58256418, compound → HCID 58256428, compound

Participants

Reaction Steps

To a stirred suspension of (S)-2,2-dimethyl-4-[(R)-3,3,3-trifluoro-2-(4-nitro-phenoxy)-propyl]-oxazolidine-3-carboxylic acid tert-butyl ester (2.66 g) in methanol (20 ml) was added 10% palladium on charcoal (326 mg) and the mixture was then stirred under an atmosphere of hydrogen at room temperature for 3 hours. The mixture was then filtered through celite and the filtrate was concentrated in vacuo to afford (S)-4-[(R)-2-(4-amino-phenoxy)-3,3,3-trifluoro-propyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (1.80 g, 73%) as a yellow viscous oil. MS (ISP): 405.4 ([M+H]+), 349.3 ([M+H—C4H8]+), 305.3 ([M+H—C4H8—CO2]+).

Provenance & Evidence