HCID 58256332, compound → HCID 67151744, compound

Participants

Reaction Steps

To a stirred solution of 2-{4-[2-((S)-2-amino-4,5-dihydro-oxazol-4-yl)-ethyl]-phenyl}-6-chloro-2,3-dihydro-isoindol-1-one (9 mg) in methanol (3 ml) was added 10% paladium on charcoal (2.7 mg) and the mixture was then stirred under an atmosphere of hydrogen at room temperature for 2 hours. The mixture was then filtered through celite and the filtrate was concentrated in vacuo to afford (S)-2-(4-(2-(2-amino-4,5-dihydrooxazol-4-yl)ethyl)phenyl)isoindolin-1-one hydrochloride (9 mg, 55%) as a white solid. MS (ISP): 322.2 ([M+H]+)

Provenance & Evidence