Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate → Methyl 2-methoxy-4-(trifluoromethyl)pyrimidine-5-carboxylate

Participants

Reaction Conditions

Reaction Steps

Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate (1128 mg) was dissolved in MeOH (23 ml) before addition of sodium methoxide (380 mg), the reaction mixture was stirred for 2 hours in a sealed tube at 110° C. The solvent was evaporated, the product dissolved in ethyl acetate and washed with water, the organics were dried over Na2SO4, and concentrated in vacuo to afford title compound as a colourless oil. MS (ISP) 237.0 ([M+H]+)

Provenance & Evidence