HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butoxy bis(dimethylamino)methane → Methyl 3-(2-chloro-6-fluorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butoxy bis(dimethylamino)methane | HCID 79885 | — |
| Reactant | Methyl 3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxylate | HCID 2775337 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Methyl 3-(2-chloro-6-fluorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate | HCID 737758 | — |
Reaction Steps
To a solution of 0.1 g (0.3708 mmol) methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate in 10 mL dry toluene, 0.15 mL (0.7417 mmol) tert-Butoxy-bis(dimethylamino)methane (Bredereck's reagent) were added. The reaction mixture was heated under reflux for 6 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354436B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-3f2b68fee66544a9bad2bfbf21e978c9 |
| Source note | uspto-grants-2013_01 |