HCID 178418361, compound → HCID 178507171, compound

Participants

Reaction Steps

To a small RBF was added benzyl 1-(1H-imidazo[4,5-c]pyridin-2-yl)cyclopropylcarbamate (939 mg, 3.05 mmol) in methanol (13 ml). The flask was sealed with a septa and the solution was degassed and flushed with nitrogen several times. To the solution was then added 10% Palladium(II) on carbon (97 mg, 91 μmol), and a balloon of hydrogen was added to the top of the flask. The mixture was stirred overnight at room temperature. The mixture was pushed through a plug of celite in a Whatman Autovial (equipped with a 0.45 uM nylon membrane and a glass microfiber prefilter). Volatiles were removed giving 640 mgs (100% yield) of 1-(1H-imidazo[4,5-c]pyridin-2-yl)cyclopropanamine as a yellow solid. 1H NMR (400 MHz, CD3OD) δ ppm 1.67-1.72 (m, 2 H), 1.73-1.80 (m, 2 H), 7.92 (m, 1 H), 8.40 (d, J=7.0 Hz, 1 H), 9.05 (s, 1 H). LCMS rt=0.293 min., m/z 175.1 (M+H), 90.7% purity.

Provenance & Evidence