(1S,2S)-2-(4-chlorophenyl)spiro[cyclopropane-1,3'-indolin]-2'-one → HCID 53245851, compound

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Reaction Steps

The title compound was prepared in analogy to Example 81 starting from methyl-ethyl-3-iodobenzoate (commercially available), (1R,2R) and (1S,2S)-2-(4-chlorophenyl)spiro [cyclopropane-1,3′-indolin]-2′-one prepared as in Scheme 1 LC/MS m/e calcd. for C23H16ClNO3 389, observed (M+H)+: 390.1. 1H NMR (400 MHz, DMSO-d6) δppm 2.31-2.42 (m, 2 H) 3.42 (t, J=8.72 Hz, 1 H) 6.88 (d, J=7.58 Hz, 1 H) 7.15 (t, J=7.20 Hz, 1 H) 7.22-7.28 (m, 1 H) 7.28-7.36 (m, 3 H) 7.36-7.41 (m, 2 H) 7.60-7.70 (m, 2 H) 7.86 (s, 1 H) 7.93-8.00 (m, 1 H) 13.24 (br. s, 1 H).

Provenance & Evidence