1-Methylpiperazine → HCID 53245077, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 85 starting from 1-methylpiperazine, methyl-3-iodobenzoate (commercially available), (1R,2R) and (1S,2S)-2-(4-chlorophenyl)spiro[cyclopropane-1,3′-indolin]-2′-one prepared as in Scheme 1. LC/MS m/e calcd. for C28H26ClN3O2: 471, observed (M+H)+: 472.2 1H NMR (400 MHz, MeOD-d4) δppm 2.22-2.35 (m, 2 H) 2.98 (s, 3 H) 3.35-3.39 (m, 1 H) 6.17 (d, J=7.58 Hz, 1 H) 6.83 (t, J=7.58 Hz, 1 H) 6.96 (d, J=8.08 Hz, 1 H) 7.13-7.21 (m, 1 H) 7.27-7.33 (m, 2 H) 7.34-7.40 (m, 2 H) 7.60-7.65 (m, 1 H) 7.68-7.80 (m, 3 H).

Provenance & Evidence