Methyl 3-iodobenzoate → HCID 58305368, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 85 starting from methanesulfonamide, methyl-3-iodobenzoate (commercially available), (1R,2R) and (1S,2S)-2-(4-chlorophenyl)spiro[cyclopropane-1,3′-indolin]-2′-one prepared as in Scheme 1. LC/MS m/e calcd. for C24H19ClN2O4S: 466, observed (M+H)+: 467.2 1H NMR (400 MHz, DMSO-d6) δppm 2.31-2.41 (m, 2 H) 3.37 (s, 3 H) 3.43 (t, J=8.72 Hz, 1 H) 6.90 (d, J=7.83 Hz, 1 H) 7.16 (t, J=7.33 Hz, 1 H) 7.25 (dd, J=7.83, 1.01 Hz, 1 H) 7.27-7.35 (m, 3 H) 7.35-7.43 (m, 2H) 7.62-7.70 (m, 2 H) 7.94-7.99 (m, 2 H) 12.24 (br. s., 1 H).

Provenance & Evidence