Sodium methanesulfinate → HCID 53245140, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 92 starting from methanesulfinic acid sodium salt, 3-bromo-5-iodo-benzoic acid (commercially available), (1R,2R) and (1S,2S)-2-(4-chlorophenyl)spiro[cyclopropane-1,3′-indolin]-2′-one prepared as in Scheme 1. LC/MS m/e calcd. for C24H18ClNO55: 467, observed (M+H)+: 468.1 1H NMR (400 MHz, MeOD-d4) δppm 2.27-2.36 (m, 2 H) 3.28 (s, 3 H) 3.38 (t, J=8.59 Hz, 1 H) 6.18 (d, J=7.58 Hz, 1 H) 6.85 (t, J=7.20 Hz, 1 H) 7.00 (d, J=7.83 Hz, 1 H) 7.14-7.23 (m, 1 H) 7.28-7.40 (m, 4 H) 8.38 (t, J=1.89 Hz, 1 H) 8.49 (s, 1 H) 8.62 (s, 1 H).

Provenance & Evidence