2-Pyrrolidone → HCID 53247647, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 92 starting from 2-pyrrolidone, 3-bromo-5-iodo-benzoic acid (commercially available), (1R,2R) and (1S,2S)-2-(4-chlorophenyl)spiro[cyclopropane-1,3′-indolin]-2′-one prepared as in Scheme 1. LC/MS m/e calcd. for C27H21ClN2O4: 472, observed (M+H)+: 4731.2 1HNMR (400 MHz, MeOD-d4) δppm 2.18-2.35 (m, 4 H) 2.67 (t, J=8.08 Hz, 2 H) 3.35-3.39 (m, 1 H) 4.05 (t, J=7.07 Hz, 2 H) 6.16 (d, J=7.07 Hz, 1 H) 6.82 (t, J=7.45 Hz, 1 H) 6.97 (d, J=7.33 Hz, 1 H) 7.12-7.20 (m, 1H) 7.34 (q, J=8.67 Hz, 4 H) 7.95 (s, 1 H) 8.20 (t, J=1.89 Hz, 1 H) 8.33 (s, 1 H).

Provenance & Evidence