Methyl 4-(bromomethyl)benzoate → HCID 53247649, compound

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Reaction Steps

The title compound was prepared in analogy to Example 1 starting from 4-bromomethyl-benzoic acid methyl ester (commercially available), (1R,2S) and (1S,2R)-4-(2′-oxospiro[cyclopropane-1,3′-indoline]-2-yl)benzonitrile prepared as in Scheme 1. LC/MS m/e calcd. for C25H18ClN2O3: 394, observed (M+H)+: 395.2 1H NMR (400 MHz, DMSO-d6) δppm 2.11-2.20 (m, 1 H) 2.43-2.50 (m, 1 H) 5.10 (s, 2 H) 6.16 (d, 1 H) 6.70 (t, 1 H) 6.92 (d, 1 H) 7.08 (t, 1 H) 7.43 (d, 2 H) 7.55 (d, 2 H) 7.80 (d, 2 H) 7.93 (d, 2 H).

Provenance & Evidence