Methyl 3-(bromomethyl)benzoate → HCID 58305367, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 1 starting from 3-bromomethyl-benzoic acid methyl ester (commercially available), (1R,2S) and (1S,2R)-2-(3-chloro-4-fluorophenyl)spiro[cyclopropane-1,3′-indolin]-2′-one prepared as in Scheme 1. LC/MS m/e calcd. for C24H17ClFNO3: 421, observed (M+H)+: 422.2 1H NMR (400 MHz, DMSO-d6) δppm 2.04-2.15 (m, 1 H) 2.40-2.49 (m, 1 H) 3.21 (t, 1 H) 5.09 (s, 2 H) 6.18 (d, 1 H) 6.75 (t, 1 H) 6.96 (d, 1 H) 7.06-7.14 (m, 1 H) 7.29-7.39 (m, 2 H) 7.46-7.53 (m, 1 H) 7.56-7.65 (m, 2 H) 7.82-7.93 (m, 2 H) 13.03 (s, 1 H).

Provenance & Evidence