Dimethylamine → HCID 58305345, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 60 starting from 3-bromomethyl-benzoic acid methyl ester, dimethylamine, methylamine (commercially available), (1R,2S) and (1S,2R)-2-(4-chlorophenyl)spiro[cyclopropane-1,3′-indolin]-2′-one prepared as in Scheme 1. LC/MS m/e calcd. for C29H27ClN2O2: 470, observed (M+H)+: 471.2 1H NMR (400 MHz, MeOD-d4) δppm 2.15-2.24 (m, 2 H) 2.90 (s, 3 H) 3.06 (s, 3 H) 3.21-3.35 (m, 1 H) 5.09 (s, 2 H) 6.05 (d, J=7.58 Hz, 1 H) 6.69 (t, J=7.58 Hz, 1 H) 6.89 (d, J=8.08 Hz, 1 H) 7.01-7.10 (m, 1 H) 7.19 (d, J=8.59 Hz, 2 H) 7.25-7.38 (m, 4 H) 7.40-7.49 (m, 2 H).

Provenance & Evidence