N-(3-Aminopropyl)morpholine → HCID 67233484, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 60 starting from form 3 3-morpholinopropan-1-amine, 3-bromomethyl-benzoic acid methyl ester (commercially available), (1R,2S) and (1S,2R)-2-(4-chlorophenyl)spiro[cyclopropane-1,3′-indolin]-2′-one prepared as in Scheme 1. LC/MS m/e calcd. for C31H32ClN3O3: 529, observed (M+H)+: 530.2 1H NMR (400 MHz, MeOD-d4) δppm 2.02-2.15 (m, 2 H) 2.24 (d, J=8.59 Hz, 2 H) 3.15 (br. s., 2 H) 3.23 (d, J=8.08 Hz, 2 H) 3.25-3.31 (m, 1 H) 3.47-3.57 (m, 4 H) 3.79 (t, J=12.38 Hz, 2 H) 4.06 (br. s., 2 H) 5.14 (s, 2 H) 6.09 (d, J=7.33 Hz, 1 H) 6.73 (t, J=7.58 Hz, 1 H) 6.91 (d, J=8.08 Hz, 1 H) 7.09 (t, J=7.71 Hz, 1 H) 7.20-7.28 (m, 2 H) 7.28-7.37 (m, 2 H) 7.49 (t, J=7.71 Hz, 1 H) 7.53-7.61 (m, 1 H) 7.78 (d, J=8.08 Hz, 1 H) 7.87 (s, 1 H).

Provenance & Evidence