2-Morpholinoethylamine → HCID 53244295, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 60 starting from 2-morpholinoethanamine, 3-bromomethyl-benzoic acid methyl ester (commercially available), (1R,2S) and (1S,2R)-2-(4-chlorophenyl)spiro[cyclopropane-1,3′-indolin]-2′-one prepared as in Scheme 1. LC/MS m/e calcd. for C30H30ClN3O3: 515, observed (M+H)+: 516.21H NMR (400 MHz, MeOD-d4) δppm 2.24 (d, J=8.59 Hz, 2 H) 3.20 (br. s., 2 H) 3.29 (s, 1 H) 3.42 (t, J=5.81 Hz, 2 H) 3.69 (br. s., 4 H) 3.80 (t, J=5.81 Hz, 2 H) 4.08 (br. s., 2 H) 5.14 (d, J=1.52 Hz, 2 H) 6.09 (d, J=7.33 Hz, 1 H) 6.73 (t, J=7.58 Hz, 1 H) 6.91 (d, J=8.08 Hz, 1 H) 7.04-7.13 (m, 1 H) 7.22-7.28 (m, 2 H) 7.29-7.36 (m, 2 H) 7.50 (t, J=7.71 Hz, 1 H) 7.55-7.62 (m, 1 H) 7.80 (d, J=7.58 Hz, 1 H) 7.90 (s, 1 H).

Provenance & Evidence