Methyl 3-(bromomethyl)benzoate → HCID 58305311, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 60 starting from 1-(methylsulfonyl)piperazine, 3-bromomethyl-benzoic acid methyl ester (commercially available), (1R,2S) and (1S,2R)-2-(4-chlorophenyl)spiro[cyclopropane-1,3′-indolin]-2′-one prepared as in Scheme 1. LC/MS m/e calcd. for C29H28ClN3O4S: 549, observed (M+H)+: 550.21H NMR (400 MHz, MeOD-d4) δppm 8.19-8.05 (m, 2 H) 7.49 (s, 3 H) 7.25 (br. s., 4 H) 7.09-7.05 (m, 1H) 6.88 (br. s., 2 H) 6.50 (br. s., 2 H) 5.29-5.12 (m, 2 H) 4.23 (d, J=7.58 Hz, 1 H) 3.64-3.56 (m, 1H) 3.41 (d, J=7.58 Hz, 1 H) 3.29-3.19 (m, 1 H) 3.11 (d, J=8.08 Hz, 2 H) 3.07-2.99 (m, 2 H) 2.98-2.91 (m, 2 H) 2.88-2.75 (m, 2 H).

Provenance & Evidence