Methyl 3-(bromomethyl)benzoate → HCID 178521741, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 60 starting from 3-cyclopropyl-1H-pyrazol-5-amine, 3-bromomethyl-benzoic acid methyl ester (commercially available), (1R,2S) and (1S,2R)-2-(4-chlorophenyl)spiro[cyclopropane-1,3′-indolin]-2′-one prepared as in Scheme 1. LC/MS m/e calcd. for C30H25ClN4O2: 508, observed (M+H)+: 509.21H NMR (400 MHz, MeOD-d4) δppm 0.66-0.77 (m, 2 H) 1.02 (dd, J=8.34, 1.77 Hz, 2 H) 2.24 (d, J=8.59 Hz, 2H) 2.47-2.57 (m, 1 H) 3.26-3.32 (m, 1 H) 5.07-5.25 (m, 2 H) 5.65 (s, 1 H) 6.09 (d, J=7.58 Hz, 1 H) 6.73 (t, J=7.58 Hz, 1 H) 6.96 (d, J=7.83 Hz, 1 H) 7.07-7.14 (m, 1 H) 7.20 (d, J=8.34 Hz, 2 H) 7.31 (d, J=8.34 Hz, 2H) 7.49 (t, J=7.83 Hz, 1 H) 7.55-7.63 (m, 1 H) 7.80 (d, J=7.83 Hz, 1 H) 7.83 (s, 1 H).

Provenance & Evidence