Cyclopropanesulfonamide → HCID 53244366, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 60 starting from methyl-6-(bromomethyl)picolinate, cyclopropanesulfonamide and (1R,2S) and (1S,2R)-4-(2′-oxospiro[cyclopropane-1,3′-indoline]-2-yl)benzonitrile prepared as in Scheme 1. LC/MS m/e calcd. for C27H22N4O4S: 498, observed (M+H)+: 499.2 1HNMR (400 MHz, DMSO-d6) δppm 1.02-1.15 (m, 2 H) 1.14-1.24 (m, 2 H) 2.08-2.20 (m, 1 H) 2.43-2.48 (m, 1 H) 2.99-3.15 (m, 1 H) 3.27-3.34 (m, 1 H) 5.19 (s, 2 H) 6.14 (d, 1 H) 6.72 (t, 1 H) 6.99 (d, 1H) 7.09 (t, 1 H) 7.47 (d, 1 H) 7.59 (d, 2 H) 7.79 (d, 2 H) 7.92-8.06 (m, 2 H).

Provenance & Evidence