反应详情

The title compound was prepared in analogy to Example 81 starting from 2-(2,6-dimethylmorpholino)ethanamine, dibromo ethylene (commercially available), (1R,2S) and (1S, 2R)-2-(4-chlorophenyl)spiro[cyclopropane-1,3′-indolin]-2′-one prepared as in Scheme 1. LC/MS m/e calcd. for C26H32ClN3O2: 453, observed (M+H)+: 454.1 1HNMR (400 MHz, MeOD-d4) δppm 1.22 (dd, J=6.32, 2.27 Hz, 2 H) 1.26-1.37 (m, 6 H) 2.15-2.32 (m, 3 H) 2.43-2.67 (m, 1 H) 2.88 (br. s., 3 H) 3.26 (d, J=8.59 Hz, 2 H) 3.40-3.62 (m, 4 H) 3.70-3.96 (m, 1 H) 4.13 (br. s., 4 H) 6.05-6.21 (m, 1 H) 6.81 (t, J=7.58 Hz, 1 H) 7.06-7.18 (m, 1 H) 7.24 (d, J=8.34 Hz, 3 H) 7.29-7.38 (m, 2 H).