Methyl 3-iodobenzoate → HCID 58305409, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 85 starting from methylsulfonamide, methyl-3-iodobenzoate (commercially available), (1R,2S) and (1S,2R)-2-(4-chlorophenyl)spiro[cyclopropane-1,3′-indolin]-2′-one prepared as in Scheme 1. LC/MS m/e calcd. for C24H19ClN2O4S: 466, observed (M+H)+: 467.2 1H NMR (400 MHz, DMSO-d6) δppm 2.15 (dd, J=9.09, 4.80 Hz, 1 H) 2.44 (dd, J=8.08, 4.80 Hz, 1 H) 3.25 (t, J=8.59 Hz, 1 H) 3.41 (s, 3 H) 6.21 (d, J=7.58 Hz, 1 H) 6.79-6.88 (m, 2 H) 7.10-7.17 (m, 1 H) 7.37-7.45 (m, 4 H) 7.75 (t, J=7.83 Hz, 1 H) 7.80-7.85 (m, 1 H) 8.04 (d, J=7.83 Hz, 1 H) 8.11-8.16 (m, 1 H) 12.29 (br. s., 1 H).

Provenance & Evidence