2-Oxazolidinone → HCID 53245829, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 95 starting from oxazolidin-2-one (commercially available), 3-bromo-5-iodobenzoic acid methylester prepared in Example 92, (1R,2R) and (1S,2S)-2-(4-chlorophenyl)-2-methylspiro[cyclopropane-1,3′-indolin]-2′-one prepared as in Scheme 2. LC/MS m/e calcd. for C27H21ClN2O5: 488, observed (M+H)+: 489.1 1H NMR (400 MHz, DMSO-d6) δppm 1.66 (s, 3 H) 2.18 (d, J=4.80 Hz, 1 H) 2.38 (d, J=5.05 Hz, 1 H) 4.12 (t, J=8.08 Hz, 2 H) 4.47 (t, J=7.96 Hz, 2 H) 6.95 (d, J=8.08 Hz, 1 H) 7.15 (t, J=7.45 Hz, 1 H) 7.25-7.34 (m, 5 H) 7.45 (d, J=7.33 Hz, 1 H) 7.59-7.62 (m, 1 H) 7.85 (t, J=2.02 Hz, 1 H) 8.12 (s, 1 H).

Provenance & Evidence