2-Oxazolidinone → HCID 58305317, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 95 starting from oxazolidin-2-one, 3-bromo-5-iodobenzoic methylester (prepared as in Example 92), (1R,2R) and (1S,2S)-2-(4-chlorophenyl)-2-isopropylspiro[cyclopropane-1,3′-indolin]-2′-one prepared as in Scheme 2. LC/MS m/e calcd. for C29H25ClN2O5: 516, observed (M+H)+: 517.2 1H NMR (400 MHz, DMSO-d6) δppm 0.77 (d, 3 H) 0.89 (d, 3 H) 2.16 (d, 1 H) 2.28 (d, 1 H) 2.95-3.02 (m, 1 H) 4.17-4.25 (m, 2 H) 4.40-4.58 (m, 2 H) 5.43 (d, 1 H) 6.65-6.76 (m, 1 H) 6.78-6.91 (m, 2 H) 7.11 (t, 1 H) 7.61 (d, 1 H) 7.69 (d, 1 H) 7.79 (s, 1 H) 7.92-8.03 (m, 2 H) 8.21 (s, 1 H) 13.44 (s, 1 H).

Provenance & Evidence