2-Oxazolidinone → HCID 58305317, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 95 starting from oxazolidin-2-one (commercially available), 3-bromo-5-iodobenzoic methylester (prepared as in Example 92), (1S,2S) and (1R,2R)-2-(4-chlorophenyl)-2-isopropylspiro[cyclopropane-1,3′-indolin]-2′-one prepared as in Scheme 2. LC/MS m/e calcd. for C29H25ClN2O5: 516, observed (M+H)+: 517.21H NMR (400 MHz, DMSO-d6) δppm 0.77 (d, 3 H) 0.89 (d, 3 H) 2.16 (d, 1 H) 2.28 (d, 1 H) 2.85-3.02 (m, 1 H) 4.07-4.25 (m, 2 H) 4.41-4.59 (m, 2 H) 5.43 (d, 1 H) 6.62-6.75 (m, 1 H) 6.78-6.91 (m, 2 H) 7.11 (t, 1 H) 7.61 (d, 1 H) 7.69 (d, 1 H) 7.79 (s, 1 H) 7.92-8.03 (m, 2 H) 8.21 (s, 1 H) 13.44 (s, 1 H).

Provenance & Evidence