HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1805752Generated: October 30, 2026
Ethyl orthoformate → 5,7-Dichloropyrido[4,3-d]pyrimidin-4(3H)-one
https://huagongshe.com/reaction/1805752
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 4-Amino-2,6-dichloronicotinamide | HCID 58093052 | — |
| Product | 5,7-Dichloropyrido[4,3-d]pyrimidin-4(3H)-one | HCID 135741588 | — |
Reaction Steps
A mixture of 4-Amino-2,6-dichloronicotinamide (9.0 g, 43.7 mmol) and triethyl orthoformate (90 mL) was heated at 150° C. in a ChemGlass bomb for 6 hours and evaporated under reduced pressure to afford the title compound. 1H NMR (DMSO-d6) δ 7.72 (s, 1H), 8.31 (1H); ESI-MS m/z 216.0 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08354526B2 |
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| Source dataset | uspto-grants-2013_01 |
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| ORD ID | ord-a5961e8b85bc46b0801faa7f95526ad0 |
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| Source note | uspto-grants-2013_01 |
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