HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1805755Generated: October 31, 2026
Ethylenediamine → 7-(2-aminoethylamino)-5-(6-morpholinopyridin-3-ylamino)pyrido[4,3-d]pyrimidin-4(3H)-one
https://huagongshe.com/reaction/1805755
Participants
| Role | Name | HCID | Charge |
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| Reactant | Ethylenediamine | HCID 3301 | — |
| Reactant | 5-(6-morpholinopyridin-3-ylamino)-7-chloropyrido[4,3-d]pyrimidin-4(3H)-one | HCID 136111176 | — |
| Product | 7-(2-aminoethylamino)-5-(6-morpholinopyridin-3-ylamino)pyrido[4,3-d]pyrimidin-4(3H)-one | HCID 136111174 | — |
Reaction Steps
A mixture of starting material 5-(6-morpholinopyridin-3-ylamino)-7-chloropyrido[4,3-d]pyrimidin-4(3H)-one (20 mg, 0.055 mmol) and ethylene diamine (200 uL, used as solvent as well) was heated at 150° C. overnight. The excess diamine was removed under reduced pressure, and the residue was subject to HPLC-MS for purification to the final product 7-(2-aminoethylamino)-5-(6-morpholinopyridin-3-ylamino)pyrido[4,3-d]pyrimidin-4(3H)-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08354526B2 |
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| Source dataset | uspto-grants-2013_01 |
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| ORD ID | ord-443b762ccf0f46a6b72f40bb1d6b78dd |
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| Source note | uspto-grants-2013_01 |
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