HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonyl chloride → Tert-butyl 4-(methylsulfonyl)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | HCID 68731830 | HCID 68731830 | — |
| Product | Tert-butyl 4-(methylsulfonyl)piperazine-1-carboxylate | HCID 4496004 | — |
Reaction Steps
Scheme 2 shows the synthesis of 4-(methylsulfonyl)piperazin-1-ium chloride 8 starting by N-sulfonylation of 1-(tert-butoxycarbonyl)piperazine 6 (BOC-piperazine) with methanesulfonyl chloride to give tert-butyl 4-(methylsulfonyl)piperazine-1-carboxylate 7 which was treated with aqueous hydrogen chloride solution in 1,4-dioxane to give 8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354528B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-b3791bf6ee8e42b6aec082af7ba00c90 |
| Source note | uspto-grants-2013_01 |