Acetone → Acetone tetrahydrofuran

Participants

Reaction Steps

R,R′-atracurium besylate mixture (500 mg, isomer ratio −58:36:6) was placed in a 100 mL flask. 35 mL of THF was added to the solid followed by 3.5 mL of acetone. The mixture was stirred in an ice bath and HBF4 (48% in water, 200 μL) was added and the solution was stirred for 5 hours in the ice bath, during which time a white solid was formed. The slurry was filtered through a Buchner funnel to afford 244.6 mg (0.197 mmol, 84.5% yield from the cis isomer) of a white solid (isomer ratio −89:10.5:0.5).

Provenance & Evidence