Acetone → Acetone tetrahydrofuran

Participants

Reaction Steps

R,R′-atracurium besylate (100 mg, 94.8% purity) was placed in a vial. 7 mL of THF and 0.7 mL of acetone were added to the solid. The reaction mixture was stirred in an ice bath and HBF4 (48% in water, 40 μL, 1.25 eq.) was added and the solution was stirred for 5 hours in the ice bath, during which time a white solid was formed. The slurry was separated through a Buchner funnel to afford 39.2 mg (39.2% yield) of a white solid, having 97.2% purity.

Provenance & Evidence