Acetone → Acetone tetrahydrofuran

Participants

Reaction Steps

Crude R,R′-atracurium tetrafluoroborate (244.6 mg, isomer ratio −89:10.5:0.5) was placed in a 50 mL flask. 17 mL of THF followed by 1.7 mL of acetone were added to the white solid. The reaction mixture was stirred in an ice bath and HBF4 (48% in water, 40 μL) was added and the slurry was stirred for 5 hours in the ice bath. The slurry was filtered through a Buchner funnel to afford 90.1 mg (0.0725 mmol, 41.9% yield from the cis isomer) of a white solid having 93:7:0 isomer ratio.

Provenance & Evidence