反应详情

温度

100 °C

To a mixture of (E)-N′-(3-benzyl-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl)-N,N-dimethylformimidamide (21.2 g, 0.07 mol) in MeOH (382 mL) was added 3M NaOH (276 mL) and heated at 100° C. for 5 h. After completion of the reaction, the reaction mixture was cooled to 0° C. The solid was filtered (15.8 g, 91%) and used in the next step without further purification.

1. customAfter completion of the reaction
2. temperaturethe reaction mixture was cooled to 0° C
3. filtrationThe solid was filtered (15.8 g, 91%)
4. customused in the next step without further purification