Aluminum(III) Chloride → HCID 11962295, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 4-(5-benzyl-4-(mesityloxy)-5H-pyrrolo[3,2-d]pyrimidin-2-ylamino)benzonitrile (150 mg, 0.33 mmol) in 1,2-dichlorobenzene (13 mL) was added AlCl3 (436 mg, 3.27 mmol). The reaction mixture was heated at 160° C. for 1.5 h during which the reaction mixture became dark and homogeneous. Upon completion of the reaction, the reaction mixture was cooled and washed with NH4Cl. The combined organic layers were washed with brine, dried over Na2SO4, filtered, and concentrated in vacuo. The crude product was purified by column chromatography, eluting with Hexanes:Ethyl acetate (5:1-1:1) provided the product as a tan solid (27.8 mg, 23%).

Provenance & Evidence