HCID 86657399, compound → HCID 86657398, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 10% palladium on carbon (7.9 mg, 0.074 mmol) in a solution of 4-(2-{[bis(benzyloxy)phosphoryl]oxy}ethyl)-2-methoxyphenyl (1R ,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-((tert-butoxycarbonyl){[4′-fluoro-5′-isopropyl-2′-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)propyl carbonate (86.2 mg, 0.074 mmol) in ethanol (5.7 mL) was stirred under H2 (double balloon pressure) at 25° C. for 5 h. The reaction mixture was filtered through a plug of Celite and the filtrate was concentrated in vacuo to afford (1R,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-((tert-butoxycarbonyl){[4′-fluoro-5′-isopropyl-2′-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)propyl 2-methoxy-4-[2-(phosphonooxy)ethyl]phenyl carbonate. LCMS calc.=1008.8; found=1008.8 (M+Na)+.

Provenance & Evidence