HCID 86761745, compound → HCID 86761744, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 10% palladium on carbon (9.13 mg, 8.57 μmol) in a solution of (1R,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-((tert-butoxycarbonyl){[4′-fluoro-5′-isopropyl-2′-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)propyl 2-phenyl-1,3-dioxan-5-yl carbonate (78.7 mg, 0.086 mmol) in EtOAc (6.60 mL) was stirred under H2 (double balloon pressure) at 25° C. for 15 h. The reaction mixture was filtered through a plug of Celite and the filtrate was concentrated in vacuo to afford (1R,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-((tert-butoxycarbonyl){[4′-fluoro-5′-isopropyl-2′-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)propyl 2-hydroxy-1-(hydroxymethyl)ethyl carbonate. LCMS calc.=852.26; found=852.10 (M+Na)+.

Provenance & Evidence