Hydrochloric Acid → HCID 86761746, compound

Participants

Reaction Steps

A solution of (1R,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-((tert-butoxycarbonyl){[4′-fluoro-5′- isopropyl-2′-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)propyl 2-(phosphonooxy)-1-[(phosphonooxy)methyl]ethyl carbonate (46.7 mg, 0.047 mmol) in HCl saturated EtOAc (3 mL) was stirred at 25° C. for 1 h. The reaction mixture was concentrated in vacuo to afford (8R,9S)-8-[3,5-bis(trifluoromethyl)phenyl]-N-{[4′-fluoro-5′-isopropyl-2′-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}-1,1-dihydroxy-6-oxo-4-[(phosphonooxy)methyl]-2,5,7-trioxa-1λ5-phosphadecan-9-aminium1-oxide chloride, as a colorless glass/solid. LCMS calc.=890.16; found=890.00 (M+H)+.

Provenance & Evidence