HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 68771066, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | 2-Benzylpyrrolidine | HCID 339556 | — |
| Reactant | 1-Benzyl-4-(2-methylphenyl)pyrrolidine-3-carboxylic acid | HCID 53394838 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 68771066 | HCID 68771066 | — |
Reaction Steps
To 1-Benzyl-4-(2-methylphenyl)pyrrolidine-3-carboxylic acid (0.088 g, 0.298 mmol) in CH2Cl2 (1.490 ml) was added BOP (0.138 g, 0.313 mmol), DIPEA (0.208 ml, 1.192 mmol), and 2-benzylpyrrolidine (0.050 g, 0.313 mmol). The solution was stirred at room temperature for 4 hours. Concentrate, filter, and purify on reverse phase HPLC. HRMS (M+H)=439.2739
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354545B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-210d084a35fd4b5abf7c0ad6a93d80f3 |
| Source note | uspto-grants-2013_01 |