Thiophenol → Ethyl 4-chloro-3-(2-(4-methylthiazol-2-ylamino)-5-(phenylthio)pyridin-3-yloxy)benzoate

HRID 1806042Notes

Reaction equation

HRID 1806042 reaction equation
Br[C:2]1[CH:3]=[C:4]([O:15][C:16]2[CH:17]=[C:18]([CH:24]=[CH:25][C:26]=2[Cl:27])[C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:5]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH3:14])[N:13]=2)=[N:6][CH:7]=1.[C:28]1([SH:34])[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[Cl:27][C:26]1[CH:25]=[CH:24][C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:17][C:16]=1[O:15][C:4]1[C:5]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH3:14])[N:13]=2)=[N:6][CH:7]=[C:2]([S:34][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 7969ThiophenolHCID 24765938HCID 24765938, compound

Product 1

HCID 86631477Ethyl 4-chloro-3-(2-(4-methylthiazol-2-ylamino)-5-(phenylthio)pyridin-3-yloxy)benzoate

Procedure

Prepared according to the method of Example 13, using Ethyl 3-(5-bromo-2-(4-methylthiazol-2-ylamino)pyridin-3-yloxy)-4-chlorobenzoate and benzenethiol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d17ec0e445d9439c896b9fd73cc6ed6d
Source dataset
uspto-grants-2013_01
Patent number
US08354540B2

Reaction notes

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