1,1-Dimethylethyl 4-[[(methylsulfonyl)oxy]-2-pyridinylmethyl]-1-piperidinecarboxylate → HCID 86631503, compound

HRID 1806084Notes

Reaction equation

HRID 1806084 reaction equation
[CH2:1]([C:9]1[N:10]=[C:11]([NH:14][C:15]2[N:20]=[CH:19][C:18]([S:21]CCC(OC)=O)=[CH:17][C:16]=2[O:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[S:12][CH:13]=1)[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.CC([O-])(C)C.[K+].CS(O[CH:46]([C:60]1[CH:65]=[CH:64][CH:63]=[CH:62][N:61]=1)[CH:47]1[CH2:52][CH2:51][N:50]([C:53]([O:55][C:56]([CH3:59])([CH3:58])[CH3:57])=[O:54])[CH2:49][CH2:48]1)(=O)=O>>[CH2:1]([C:9]1[N:10]=[C:11]([NH:14][C:15]2[N:20]=[CH:19][C:18]([S:21][CH:46]([C:60]3[CH:65]=[CH:64][CH:63]=[CH:62][N:61]=3)[CH:47]3[CH2:48][CH2:49][N:50]([C:53]([O:55][C:56]([CH3:57])([CH3:58])[CH3:59])=[O:54])[CH2:51][CH2:52]3)=[CH:17][C:16]=2[O:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[S:12][CH:13]=1)[CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 185391711,1-Dimethylethyl 4-[[(methylsulfonyl)oxy]-2-pyridinylmethyl]-1-piperidinecarboxylateHCID 23665647Potassium tert-butoxideHCID 57742608HCID 57742608, compound

Product 1

HCID 86631503HCID 86631503, compound

Procedure

Prepared according to the method of Example 16 from methyl 3-(6-(4-phenethylthiazol-2-ylamino)-5-phenoxypyridin-3-ylthio)propanoate, potassium 2-methylpropan-2-olate, and tert-butyl 4-((methylsulfonyloxy)(pyridin-2-yl)methyl)piperidine-1-carboxylate.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c32d3475f3054aa19cf352b92b356d59
Source dataset
uspto-grants-2013_01
Patent number
US08354540B2

Reaction notes

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