反应详情

Added zinc powder (13.88 g, 212.2 mmol) slowly to a solution of methyl 4-(2-nitropyridin-3-ylthio)benzoate (6.16 g, 21.22 mmol) in acetic acid (75 mL) at ambient temperature in an ambient water bath. Stirred for an hour, diluted with dichloromethane, and filtered through celite. Washed the celite pad several times with dichloromethane. Concentrated the filtrate, and partitioned the residue between 2N NaOH and ethyl acetate. The organic layer was washed with water, brine, dried and concentrated to afford the title compound (5.5 g, 99.57% yield).

1. filtrationfiltered through celite
2. washWashed the celite pad several times with dichloromethane
3. concentrationConcentrated the filtrate
4. custompartitioned the residue between 2N NaOH and ethyl acetate
5. washThe organic layer was washed with water, brine
6. customdried
7. concentrationconcentrated