4-(3-(2-Nitropyridin-3-yloxy)phenyl)morpholine → 3-(3-Morpholinophenoxy)pyridin-2-amine

Participants

Reaction Steps

In a 125 mL round-bottom flask, 4-(3-(2-nitropyridin-3-yloxy)phenyl)morpholine (0.92 g, 3.05 mmol) was dissolved in 30 mL of ethanol and 200 mg of 10% Pd/C (Degussa type, 50% wet) added. The resulting mixture was agitated overnight under the atmospheric pressure of hydrogen. The mixture was filtered and the solvent was evaporated to give the title compound (0.80 g, 97%) as thick oil.

Provenance & Evidence