Triacetoxyperiodinane → HCID 86631522, compound

HRID 1806148Notes

Reaction equation

HRID 1806148 reaction equation
[Cl:1][CH2:2][CH:3]([OH:11])[CH2:4][N:5]1[CH2:9][CH2:8][CH2:7][C:6]1=[O:10].CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>ClCCl>[Cl:1][CH2:2][C:3](=[O:11])[CH2:4][N:5]1[CH2:9][CH2:8][CH2:7][C:6]1=[O:10]

Participants

4

Reactant 2

HCID 159087TriacetoxyperiodinaneHCID 66995201HCID 66995201, compound

Product 1

HCID 86631522HCID 86631522, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

1-(3-Chloro-2-hydroxypropyl)pyrrolidin-2-one (0.380 g, 2.14 mmol) was dissolved in dichloromethane (10 mL) and cooled to 0° C. Dess-Martin periodinane (0.907 g, 2.14 mmol) was added and the mixture agitated at ambient temperature for 2 hours. The mixture was loaded on silica gel chromatographic column and eluted with 1% methanol/dichloromethane to provide the title compound.

Workup

  1. washeluted with 1% methanol/dichloromethane

Sources & evidence

ORD record
ord-28a7df76dc2f4cc4b820fb35abc276ed
Source dataset
uspto-grants-2013_01
Patent number
US08354540B2

Reaction notes

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