Neopentylamine → HCID 66722757, compound

HRID 1806406Notes

Reaction equation

HRID 1806406 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][C:9](C)([CH3:41])[CH2:10][NH:11][CH2:12][C:13]1[O:17][CH:16]=[C:15]([C:18]2[CH:19]=[C:20]3[C:24](=[C:25]([C:27]([NH2:29])=[O:28])[CH:26]=2)[NH:23][CH:22]=[C:21]3[CH:30]2[CH2:35][CH2:34][N:33]([S:36]([CH2:39][CH3:40])(=[O:38])=[O:37])[CH2:32][CH2:31]2)[CH:14]=1.[CH3:43][C:44](C)(C)CN>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH:9]1([CH2:10][NH:11][CH2:12][C:13]2[O:17][CH:16]=[C:15]([C:18]3[CH:19]=[C:20]4[C:24](=[C:25]([C:27]([NH2:29])=[O:28])[CH:26]=3)[NH:23][CH:22]=[C:21]4[CH:30]3[CH2:31][CH2:32][N:33]([S:36]([CH2:39][CH3:40])(=[O:37])=[O:38])[CH2:34][CH2:35]3)[CH:14]=2)[CH2:8][CH2:44][CH2:43][CH2:41]1

Participants

3

Reactant 2

HCID 79882NeopentylamineHCID 66722753HCID 66722753, compound

Product 1

HCID 66722757HCID 66722757, compoundYield 25.1%

Procedure

The title compound was prepared according to the general procedure of 5-(5-{[(2,2-dimethylpropyl)amino]methyl}-3-furanyl)-3-[1-(ethylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamide trifluoroacetate, substituting 1-cyclopentylmethanamine (137 mg, 1.4 mmol) for 2,2-dimethyl-1-propanamine to afford 22 mg of the title compound (25.1%).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-a5786998051141e1a003a8142653b436
Source dataset
uspto-grants-2013_01
Patent number
US08354406B2

Reaction notes

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